First authors contribution to journal


First authors contribution to journal

The very first manuscript submitted to our journal was from Ilona Sadok and Katarzyna Tyszczuk-Rotko , corresponding author was  Katarzyna Tyszczuk-Rotko entitled “New, Simple and Sensitive Voltammetric Procedure for Determination of Paracetamol in Pharmaceutical Formulations

A new, simple and sensitive adsorptive stripping voltammetric procedure for determination of paracetamol at a lead film glassy carbon electrode modified with Nafion film (Nafion/PbF/GCE) in pharmaceutical formulations was described. Deposition of lead film on a glassy carbon electrode from 0.1 mol L-1 HNO3 at the potential of -1.4 V was performed. The Nafion film coating was carried out by applying a 0.5 µL drop of 1% (w/v) Nafion solution onto the lead film electrode surface. At the potential of -1.45 V for 60 s paracetamol was accumulated by adsorption on the electrode from 0.1 mol L-1 H2SO4. Experimental results indicate excellent linear correlation between the paracetamol peak current and its concentration in the range from 5 × 10-7 to 1 × 10-2 mol L-1 with accumulation time equal to 60 s. The detection and quantification limits were 1.72 × 10-7 mol L-1 and 5.97 × 10-7 mol L-1, respectively. The elaborated procedure was successfully applied for determination of paracetamol in commercially available pharmaceutical formulations.

The highlights in the manuscript were :- Nafion covered lead film glassy carbon electrode; Adsorptive stripping determination; Paracetamol determination; Pharmaceutical analysis .

Various types of reagents were used in the work like :-All chemicals used were analytical grade and were used without further purification. Paracetamol (PA) and Nafion 5% (w/w) were obtained from Sigma-Aldrich, while HNO3 65%, H2SO4 95%, C2H5OH 96% were purchased from POCh. 0.01 mol L-1 solution of Pb(NO3)2 was prepared from reagent obtained from Sigma. 0.1 mol L-1 HNO3 and 0.1 mol L-1 H2SO4 used as supporting electrolytes were prepared by diluting concentrated solutions. The stock solution of PA (0.01 mol L-1) was prepared in deionized water before starting the set of experiments and stored at 4 ºC in the dark until used. Nafion (5% w/w solution) was diluted with ethanol, in order to reach a 1% w/v concentration. All solutions were prepared using ultra-purified water (>18 MΩ cm) supplied by a Milli-Q system (Millipore, UK).

 Apparatus used were :- The voltammetric experiments were performed using μAutolab analyser made by Eco Chemie, the Netherlands. The measurements were carried out using a classical three - electrode quartz cell of 10 mL volume. A modified glassy carbon electrode with the diameter of 1 mm was used as the working electrode. The GC electrode was polished daily using 0.3 μm alumina slurry on a Buehler polishing pad. A platinum wire and Ag/AgCl (3 mol L-1 KCl) were used as auxiliary and reference electrodes, respectively. The pH measurements were made using an Elmetron pH meter CI-316.

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