Aim To investigate neurological elements influencing personal satisfaction (QoL) in kids and youngsters with ataxia-telangiectasia (A-T), from both youngster and parent point of view. Method 24 kids/youngsters with A-T (mean age 11.2 ± 3.5 years; 13 males) and 20 parents were recruited, and after an average of 3.4 years, 58% were reassessed. Members finished the PedsQL QoL appraisal. Neurological examination was structured for participants with A-T. QoL information from 20Keesolid controls and their folks was utilized for correlation. Results Over time, children and young people with A-T rated their quality of life higher than their parents did, and there was no longitudinal change. The lower parental income was correlated with the child participant's older age. Interpretation In A-T, child and young person QoL ratings are not influenced by neurological disability; however, certain aspects of neurological disability do predict parent-proxy ratings, but QoL does not decrease over time. These results may indicate resilience in the face of a complicated disorder that limits one's ability to live.