Reversion-Inducing Cysteine-Rich Protein With Kazal Motifs (RECK) In Angiogenesis Of Microvessels In Glioblastoma

Reversion-inducing cysteine-rich protein with Kazal motifs (RECK) may play a role in tumor angiogenesis. Glioblastomas, the most malignant type of primary brain tumor, are highly vascularized. Little is known about the role of RECK in angiogenesis of glioblastomas. The aims of this study were to characterize RECK expression and investigate the role of RECK in glioblastomas.

Tumor samples from 50 patients with glioblastoma and brain tissue samples from neurologically normal controls were immunohistochemically stained for RECK, CD34, and vascular endothelial growth factor (VEGF). RECK was expressed in endothelial cells but not tumor cells. A significant correlation between microvessel density (MVD) according to RECK and CD34 was revealed. However, RECK expression was remarkably weak in glomeruloid vessels. MVD according to RECK staining was significantly lower than MVDto CD34 staining in the group with glomeruloid vascular proliferation, which was related with high expression of VEGF.

RECK expression was observed in endothelial cells of microvessels in normal brain and the patients with glioblastoma. However, RECK expression was remarkably downregulated in endothelial cells of glomeruloid vessels. Thus, RECK may act during angiogenesis in glioblastomas, especially in forming simple vessels as microvessels rather than glomeruloid vessels.

In summary, RECK expression was found only in endothelial cells especially in microvessels in glioblastomas. The expression of RECK was remarkably decreased in glomeruloid vessels which was related with high expression of VEGF. RECK may act during angiogenesis of microvessel formation; however the mechanism of RECK-mediated angiogenesis remains unclear. Further research examining RECK expression in tumor cells and other cells, especially vascular endothelial cells, is needed, and the research of RECK might help still more to elucidate physiological angiogenesis and pathological angiogenesis in involving cancer development.

Journal of Clinical & Molecular Pathology is a multidisciplinary peer-reviewed journal that publishes manuscripts on clinical pathology, anatomic pathology, and application of molecular biology, biochemistry, genetics, proteomics, chemistry, hematology and microbiology for the diagnosis of diseases. The journal focuses on the publication of manuscripts showcasing current concepts and techniques as well as novel findings in the field of clinical and molecular pathology.

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