To provide the RNA and protein complexity needed to control gene expression, RNA editing is essential. Correct RNA editing preserves organism development and cell function. Diseases and cancer may result from an imbalance in the RNA editing machinery. Though few studies have been reported in the realm of natural products that target RNA editing for disease and cancer therapy, it has recently been acknowledged as a target for drug discovery. Therefore, medicinal natural compounds may be able to target RNA editing. We present a literature summary of the biological effects of RNA editing on gene expression, illnesses, malignancies, and medications in this study. Additionally, a summary of the RNA editing bioinformatics resources was provided.